The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation
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چکیده
منابع مشابه
The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation.
The Hippo signaling pathway is a major regulator of organ size. In the liver, Hippo pathway deregulation promotes hyperplasia and hepatocellular carcinoma primarily through hyperactivation of its downstream effector, YAP. The LATS2 tumor suppressor is a core member of the Hippo pathway. A screen for LATS2-interacting proteins in liver-derived cells identified the transcription factor SREBP2, ma...
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Malignant mesothelioma (MM) is an aggressive neoplasm associated with asbestos exposure. We carried out genome-wide array-based comparative genomic hybridization analysis with 14 MM cell lines. Three cell lines showed overlapping homozygous deletion at chromosome 13q12, which harbored the LATS2 (large tumor suppressor homolog 2) gene. With 6 other MM cell lines and 25 MM tumors, we found 10 ina...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2016
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.274167.115